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case report, it was elucidated that the medial temporal lobe is an important neural structure related to episodic memory and that patients with injury to this region may exhibit both anterograde and retrograde amnesia. The medial temporal lobe is a typical area where a lesion after brain injury causes episodic memory impairment. In contrast, retrograde amnesia refers to failure to recall memories of events from before the onset. Anterograde amnesia refers to amnesia involving events after the onset. This case demonstrates that, even after exhibiting retrograde amnesia, if its duration is relatively short and physical function and other higher-order brain functions are sustained, social rehabilitation-including work reinstatement-is feasible.Įpisodic memory impairment is classified as anterograde or retrograde amnesia in accordance with the time of onset. Moreover, after discharge from hospital, smooth work reinstatement was possible. Despite exhibiting retrograde amnesia, he had no difficulty in his daily life in the ward. Based on these observations, the patient was considered to exhibit focal retrograde amnesia due to limbic encephalitis. However, the patient exhibited impairments related to autobiographical memory and memory of events 4 - 5 years before the onset of limbic encephalitis. After transfer to a convalescent and rehabilitation hospital, various neuropsychological tests were conducted but no apparent functional decline was observed in intellectual function, attention, memorization, or retention.

Immediately after the encephalitis onset, mental symptoms-including impaired consciousness, disorientation, hallucinations, and delusions-appeared however, his condition improved with medical treatment.

An abnormal MRI signal was observed in the right medial temporal lobe. The patient in question was a right-handed man in his 60s who developed focal retrograde amnesia due to limbic encephalitis. This case study addresses episodic memory impairment or focal retrograde amnesia related to limbic encephalitis.